Once opened, you have until your roster is about 1/2 infected before blood will really become an issue, so the goal is to prepare for the next Court boss before or near to that point. If you do not complete that first mission, you will never have infestation and cannot get infected by any means, so you have all the time in the world to prepare. This gives you plenty of time to generate a little spare blood and ensures you have the smoothest time possible when you actually decide to go to the Court. Leave the first CC Mission until heroes are pushing towards Veteran level. This will repeat until the very final CC boss is dead, which is when you can individually cure the curse via the Sanitarium like any other disease. There will be no way to remove the infection from a hero without a) killing a Fanatic for a limited cure or b) killing a main CC boss (which cleanses the whole roster and restarts the cycle). putting an infected and non-infected hero in the Tavern together. The Crimson Court disease can also be spread to other heroes by placing infected heroes in activities with uninfected heroes - eg.
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